SANTA CLARA, Calif. (AP) – San Francisco 49ers quarterback Trey Lance was taken off the field on a cart after injuring his right ankle.

Lance went down after running the ball on the second drive of the game against the Seattle Seahawks. A cart came out on the field and Lance’s leg was put into an air cast before he was taken off.

The 49ers announced he would not return. Lance’s teammates and several Seahawks players paid him respect before he left the field and was replaced by former starter Jimmy Garoppolo. Lance had taken over the starting job this season from Garoppolo after being drafted third overall in 2021.