SIOUX FALLS, S.D. (KELO) — The Department of Health has issued a warning to the public and medical professionals about the threat of fentanyl mixed with xylazine.

The DEA has reported that this mixture is becoming increasingly widespread and poses a significant risk to public health.

The combination of these two substances can lead to respiratory depression, seizures, and even death.

While naloxone — known commercially as Narcan — can restore the breathing of people who have overdosed on fentanyl, it doesn’t work against xylazine, according to Dr. Tim Southern, public health laboratory administrator for the South Dakota Department of Health.