User uShare Login | Register
Login
Register

Along with posting photos, videos, and stories, your uShare account lets you post Classified Ads, recipes on What's For Dinner, and Announcements.


53° View Weather Current Conditions Sioux Falls Change Location
Set Weather Options

RADAR LOCATION

TEMPERATURE LOCATION

Share your Photos, Videos, and Stories on uShare! Click here to get started.

News

[0] My Saved Articles
Back to all news

Business

Find local businesses
on the KELO Pages!

 

Sanford Research Secures Two NIH Grants

August 28, 2013, 2:08 PM

Sanford Research Secures Two NIH Grants
SIOUX FALLS, SD -

A pair from Sanford Research has received separate grants from the National Institutes of Health (NIH) totaling more than $2.6 million for studies involving genomic proteins and a cancer-killing drug.

Kyle J. Roux, PhD, earned a five-year, $1.52 million award from the NIH’s National Institute of General Medical Sciences (NIGMS) for his project titled “Developing methods for proximity-dependent protein labeling.”

Keith Miskimins, PhD, and his study, “Molecular mechanisms by which the diabetic drug metformin kills cancer cells,” will receive more than $1.18 million over four years from the NIH’s National Cancer Institute (NCI).

Last year, Dr. Roux unveiled a new way to identify the proximity and interactions between proteins in living cells called BioID.  The system provides insight into the underlying mechanisms of disease. His grant will allow him to further develop BioID and advance the rate at which scientists characterize proteins and their interactions, which helps in the design of therapies for human disease.

“With the human genome sequenced, we have now shifted our attention toward the challenging task of characterizing the protein products of that genome,” said Dr. Roux. “The results of this study will provide the research community with the fundamental knowledge of the capabilities of BioID.”

Dr. Miskimins’ study will explore the molecular and cellular mechanisms by which metformin, a drug used to treat type 2 diabetes, kills cancer cells. In cultured cells and animal models, metformin has been found to kill cancer cells and slow tumor growth, but the drug behaves differently when other compounds are present or nutrient availability changes.

“We want to understand how the combinations of other compounds and nutrients affect cancer cells at the molecular level and provide a rationale for how they might be used clinically,” said Dr. Miskimins. “While this study will primarily focus on breast cancer, the results could be applicable to many types of cancer.”

This is the third NIH grant for Sanford Research this summer.  In July, Michael Kruer, MD, a Sanford pediatric neurologist and neurogeneticist, was awarded $860,000 in NIH funding to further genetic research on juvenile Parkinson's disease and dystonia.

The NIH, a part of the U.S. Department of Health and Human Services Policy, is the nation’s medical research agency.

Disclaimer: This story has been reviewed but not edited or fact-checked. Views of the author are not necessarily those of this station, its owners, officers, agents or employees.

 

Previous Story

Next Story




 
Find Local Businesses on KELO Pages!

View business

You may also like

Valentino's Restaurant For Sale

10/20/2014 12:18 PM

Prime real estate on 41st Street in Sioux Falls is for sale. Valentino's Restaurant at 41st Street and Western Avenue has been listed for $1.35 mi...

Full Story
Long John Silver's Closes, Building For Sale

10/20/2014 12:31 PM

A longtime fast food option in Sioux Falls, the Long John Silver's restaurant is closing after more than 30 years in business. 

Full Story
Pierre Woman Wins On In-Flight Game Show

10/17/2014 12:10 PM

A South Dakotan is a winner on the Allegiant Airlines' first in-flight game show called "The Game Plane."  The reality show is film...

Full Story
SD Gas Prices Jump While Nation Approaches Four-Year Low

10/21/2014 11:00 AM

Gas prices have fallen to a nearly four-year low nationwide at an average of $3.09 a gallon.  AAA South Dakota says U.S. gas prices could drop to...

Full Story
Pop-Up Holiday Shop Coming to Downtown Sioux Falls

10/15/2014 11:45 AM

Unglued: Christmas Market, will open in the space formerly occupied by the Book Shop in the Carpenter Building on Phillips Avenue from Nov. 20 through...

Full Story


Events