Veterans Affairs Secretary Eric Shinseki has resigned amid widespread troubles in the VA health care system.
President Barack Obama says he accepted the resignation with "considerable regret." He and Shinseki met in the Oval Office on Friday morning.
Shinseki had faced mounting calls to step down from lawmakers in both parties.
Shinseki's resignation comes two days after a scathing internal report found broad and deep-seated problems in the sprawling health care system. The system provides care to about 6.5 million veterans annually.
Shinseki is a retired four-star Army general who has overseen the VA since the start of Obama's presidency.