The Twins scored just three runs in the doubleheader, but Berrios (2-0) made his scant support in the nightcap hold up with the best outing of his young career.
In Game 1, Nolan Arenado homered and Mark Reynolds drove in two runs to lead the Rockies to a 5-1 victory.
MINNEAPOLIS (AP) - Nolan Arenado got Colorado going with a first-inning home run, Mark Reynolds added a two-run single and the road-tough Rockies beat the Minnesota Twins 5-1 on Thursday in the first game of a doubleheader.
German Marquez (2-2) dodged trouble over five innings to limit the damage to a sacrifice fly by Brian Dozier, and the Rockies raised their record in away games to 13-5, the best mark in the major leagues.
Greg Holland struck out Dozier to end the game for his franchise-record 18th consecutive save to start the season, after entering with runners at first and second.
Charlie Blackmon and Ian Desmond drove in runs against Twins starter Ervin Santana (6-2), who took the mound with the major league lead in ERA (1.50). Santana finished seven innings for the fifth time in nine tries, but two of the four walks he issued scored. He gave up six hits and all five runs.
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MINNEAPOLIS (AP) - Jose Berrios allowed two hits and struck out 11 over 7 2/3 innings as the Minnesota Twins beat the Colorado Rockies 2-0 on Thursday night, salvaging a split of an interleague doubleheader between the first-place teams in the AL Central and NL West.