Investigators say she was headed north on Interstate 29, just after 11 a.m., when her 2001 Chevy Blazer struck a guard rail. Her rear tire went up over a concrete wall, sending the vehicle crashing down onto 271st Street.
The 22-year-old is at a Sioux Falls hospital with life threatening injuries.
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A woman is hospitalized after her SUV went off an interstate bridge two miles south of Sioux Falls and crashed onto the road below.